Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex.

ABSTRACT: It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential as

SUBMITTER: Takeuchi H 

PROVIDER: S-EPMC8596941 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature