COVID-19 and renin angiotensin aldosterone system: Pathogenesis and therapy.

ABSTRACT:

Aims

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the ACE2 component of the renin-angiotensin aldosterone system (RAAS) and infects the human cells. The aims of the present review were to look at the role and alteration of the RAAS components in SARS-CoV-2 infection, therapeutic approaches, and clinical trials in this field.

Methods

We surveyed the literature (PubMed, Web of Science, and Scopus) till August 18, 2021, and 59 published papers regarding the components of the RAAS and their role and alterations in SARS-CoV-2 infection along with various COVID-19 therapies based on the RASS components were included in the study.

Results

ACE inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor inhibitors are agents that sign

SUBMITTER: Babajani F 

PROVIDER: S-EPMC8596942 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature