Identification of miR-499a-5p as a Potential Novel Biomarker for Risk Stratification in Endometrial Cancer.

ABSTRACT:

Introduction

The Cancer Genome Atlas (TCGA) project identified four distinct prognostic groups in endometrial cancer (EC), among which two are correlated with an intermediate prognosis: the MisMatch Repair-deficient (MMRd) and the No Specific Molecular Profile (NSMP) groups. The two groups represent a heterogeneous subset of patients frequently harboring CTNNB1 alterations with distinctive clinicopathologic features. The study aimed to evaluate the miRNA expression in ECs to identify potential biomarkers of prognosis.

Methods

We analyzed miRNA expression in 72 ECs classified as MMRd or NSMP including 15 ECs with CTNNB1 mutations. In the discovery step, miRNA expression was evaluated in 30 cases through TaqMan miRNA arrays. Subsequently, four miRNAs were validated in the tota

SUBMITTER: Ravegnini G 

PROVIDER: S-EPMC8597024 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature