C-C Cross-Couplings from a Cyclometalated Au(III) C ∧ N Complex: Mechanistic Insights and Synthetic Developments.

ABSTRACT: In recent years, the reactivity of gold complexes was shown to extend well beyond π-activation and to hold promises to achieve selective cross-couplings in several C-C and C-E (E=heteroatom) bond forming reactions. Here, with the aim of exploiting new organometallic species for cross-coupling reactions, we report on the Au(III)-mediated C(sp² )-C(sp) occurring upon reaction of the cyclometalated complex [Au(C^CH2 N)Cl₂ ] (1, C^CH2 N=2-benzylpyridine) with AgPhCC. The reaction progress has been monitored by NMR spectroscopy, demonstrating the involvement of a number of key intermediates, whose structures have been unambiguously ascertained through 1D and 2D NMR analyses (¹ H, ¹³ C, ¹ H-¹ H COSY, ¹

SUBMITTER: Bonsignore R 

PROVIDER: S-EPMC8597034 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature