Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo.

ABSTRACT: Complex structures derived from multiple tissue types are challenging to study in vivo, and our knowledge of how cells from different tissues are coordinated is limited. Model organisms have proven invaluable for improving our understanding of how chemical and mechanical cues between cells from two different tissues can govern specific morphogenetic events. Here we used Caenorhabditis elegans as a model system to show how cells from three different tissues are coordinated to give rise to the anterior lumen. While some aspects of pharyngeal morphogenesis have been well-described, it is less clear how cells from the pharynx, epidermis and neuroblasts coordinate to define the location of the anterior lumen and supporting structures. Using various microscopy and software approaches, we define

SUBMITTER: Grimbert S 

PROVIDER: S-EPMC8597047 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature