Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.

ABSTRACT:

Background

Cross-sectional studies suggest normal appearing white matter (NAWM) integrity loss may lead to cortical atrophy in late-stage relapsing-remitting multiple sclerosis (MS).

Objective

To investigate the relationship between NAWM integrity and cortical thickness from first clinical presentation longitudinally.

Methods

NAWM integrity and cortical thickness were assessed with 3T magnetic resonance imaging (MRI) in 102 patients with clinically isolated syndrome or early MS (33.2 (20.1-60.1) years old, 68% female) from first clinical presentation over 2.8 ± 1.6 years. Fifty healthy controls (HCs) matched for age and sex were included. NAWM integrity was evaluated using the standardized T1w/T2w ratio (sT1w/T2w). The association between sT1w/T2w and cortical thickne

SUBMITTER: Cooper G 

PROVIDER: S-EPMC8597181 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature