RNAseq of TGF-β receptor type I kinase-dependent genes in oral fibroblast exposed to milk.

ABSTRACT:

Background

Milk is a rich source of natural growth factors that may support oral tissue homeostasis and wound healing. We had shown earlier that blocking TGF-β receptor type I kinase with the inhibitor SB431542 abolished the expression of IL11 and other genes in human gingival fibroblasts exposed to the aqueous fraction of milk. Our aim was to identify the entire signature of TGF-β receptor type I kinase-dependent genes regulated by the aqueous fraction of human milk.

Result

RNAseq revealed 99 genes being strongly regulated by milk requiring activation of the SB431542-dependent TGF-β receptor type I kinase. Among the SB431542-dependent genes is IL11 but also cadherins, claudins, collagens, potassium channels, keratins, solute carrier family proteins, transcription factors, t

SUBMITTER: Panahipour L 

PROVIDER: S-EPMC8597240 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature