Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning.

ABSTRACT:

Background

There is no consensus regarding the clinical target volume (CTV) margins in radiotherapy for glioma. In this study, we aimed to perform a complete macropathologic analysis examining microscopic tumor extension (ME) to more accurately define the CTV in glioma.

Methods

Thirty-eight supra-total resection specimens of glioma patients were examined on histologic sections. The ME distance, defined as the maximum linear distance from the tumor border to the invasive tumor cells, was measured at each section. We defined the CTV based on the relationships between ME distance and clinicopathologic features.

Results

Between February 2016 and July 2020, a total of 814 slides were examined, corresponding to 162 slides for low-grade glioma (LGG) and 652 slides for high-g

SUBMITTER: Nie S 

PROVIDER: S-EPMC8597244 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature