Linezolid Population Pharmacokinetics in South African Adults with Drug-Resistant Tuberculosis.

ABSTRACT: Linezolid is widely used for drug-resistant tuberculosis (DR-TB) but has a narrow therapeutic index. To inform dose optimization, we aimed to characterize the population pharmacokinetics of linezolid in South African participants with DR-TB and explore the effect of covariates, including HIV coinfection, on drug exposure. Data were obtained from pharmacokinetic substudies in a randomized controlled trial and an observational cohort study, both of which enrolled adults with drug-resistant pulmonary tuberculosis. Participants underwent intensive and sparse plasma sampling. We analyzed linezolid concentration data using nonlinear mixed-effects modeling and performed simulations to estimate attainment of putative efficacy and toxicity targets. A total of 124 participants provided 444 plasma sa

SUBMITTER: Abdelwahab MT 

PROVIDER: S-EPMC8597769 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature