Rhodium-catalysed ortho-alkynylation of nitroarenes.

ABSTRACT: The ortho-alkynylation of nitro-(hetero)arenes takes place in the presence of a Rh(iii) catalyst to deliver a wide variety of alkynylated nitroarenes regioselectively. These interesting products could be further derivatized by selective reduction of the nitro group or palladium-catalysed couplings. Experimental and computational mechanistic studies demonstrate that the reaction proceeds via a turnover-limiting electrophilic C-H metalation ortho to the strongly electron-withdrawing nitro group.

SUBMITTER: Tan E 

PROVIDER: S-EPMC8597868 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature