C/EBPZ modulates the differentiation and proliferation of preadipocytes.

ABSTRACT:

Background/objectives

This study investigated the functions of CCAAT/enhancer-binding protein zeta (C/EBPZ; Gene ID: 10153) in adipose tissue.

Subjects/methods

Bioinformatics analysis were used to study the expression pattern of C/EBPZ in human adipose tissue. The expression and function of C/EBPZ in adipose tissue were further studied using chicken as animal model in vivo and in vitro.

Results

The human C/EBPZ transcripts were greater and more stable in subcutaneous adipose tissue than in visceral adipose tissue (P < 0.01), and they were increased with age in adipose tissue (P < 0.05). In addition, the chicken C/EBPZ transcripts (C/EBPZ /ACTB) of visceral (abdominal) adipose tissue were significantly different between fat and lean broilers and decreased with age duri

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8597877 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature