M⁵C Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Papillary Thyroid Carcinoma.

ABSTRACT: Recently, immune response modulation at the epigenetic level is illustrated in studies, but the possible function of RNA 5-methylcytosine (m⁵C) modification in cell infiltration within the tumor microenvironment (TME) is still unclear. Three different m⁵C modification patterns were identified, and high differentiation degree was observed in the cell infiltration features within TME under the above three identified patterns. A low m⁵C-score, which was reflected in the activated immunity, predicted the relatively favorable prognostic outcome. A small amount of effective immune infiltration was seen in the high m⁵C-score subtype, indicating the dismal patient survival. Our study constructed a diagnostic model using the 10 signature genes highly rela

SUBMITTER: Li F 

PROVIDER: S-EPMC8597900 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature