Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.

ABSTRACT:

Background

Noninvasive molecular imaging of recent ischemia can potentially be used to diagnose acute coronary syndrome (ACS) with high accuracy.

Objectives

The authors hypothesized that bedside myocardial contrast echocardiography (MCE) ischemic memory imaging could be achieved with phosphatidylserine microbubbles (MB_PS) that are retained in the microcirculation via ischemia-associated endothelial activation.

Methods

A dose-finding study was performed in healthy volunteers (n = 17) to establish optimal MB_PS dosing. Stable patients with ACS (n = 30) and confirmed antecedent but resolved myocardial ischemia were studied within 2 hours of coronary angiography and percutaneous coronary intervention (PCI) when indicated. MCE molecular imaging was per

SUBMITTER: Davidson BP 

PROVIDER: S-EPMC8597917 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature