Cancer Stem Cell Assay for the Treatment of Platinum-Resistant Recurrent Ovarian Cancer.

ABSTRACT:

Background

Disease recurrence and progression of ovarian cancer is a common event, which is accompanied by the development of platinum-resistant or refractory disease. The presence of chemo-resistant Cancer Stem Cells (CSCs) contribute to tumor propagation, maintenance, and treatment resistance of this difficult to treat disease. We have developed ChemoID, a cytotoxic synergy assay against CSCs that identifies the most effective chemotherapy treatment from a panel of FDA-approved chemotherapies using fresh cancer biopsies.

Patients and methods

Ascites or interventional radiology biopsies were collected under physician order from 78 consecutive patients affected by 3^rd relapsed ovarian cancer. Test results from the assay were used when possible to treat patients wi

SUBMITTER: Howard CM 

PROVIDER: S-EPMC8597976 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature