Impact of herpes zoster vaccination on incident dementia: A retrospective study in two patient cohorts.

ABSTRACT:

Background

Herpes zoster (HZ) infection increases dementia risk, but it is not known if herpes zoster vaccination is associated with lower risk for dementia. We determined if HZ vaccination, compared to no HZ vaccination, is associated with lower risk for incident dementia.

Methods and findings

Data was obtained from Veterans Health Affairs (VHA) medical records (10/1/2008-9/30/2019) with replication in MarketScan® commercial and Medicare claims (1/1/2009-12/31/2018). Eligible patients were ≥65 years of age and free of dementia for two years prior to baseline (VHA n = 136,016; MarketScan n = 172,790). Two index periods (either start of 2011 or 2012) were defined, where patients either had or did not have a HZ vaccination. Confounding was controlled with propensity scores and

SUBMITTER: Scherrer JF 

PROVIDER: S-EPMC8597989 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature