Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells.
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ABSTRACT:
SUBMITTER: Razavi M
PROVIDER: S-EPMC8597999 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells.
Razavi Mehdi M Wang Jing J Thakor Avnesh S AS
Science advances 20211117 47
In the present work, we developed, characterized, and tested an implantable graphene bioscaffold which elutes dexamethasone (Dex) that can accommodate islets and adipose tissue–derived mesenchymal stem cells (AD-MSCs). In vitro studies demonstrated that islets in graphene–0.5 w/v% Dex bioscaffolds had a substantial higher viability and function compared to islets in graphene-alone bioscaffolds or islets cultured alone (<i>P</i> < 0.05). In vivo studies, in which bioscaffolds were transplanted in ...[more]
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