Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications.

ABSTRACT: Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel therapeutic compounds. However, interspecies differences in the mechanisms regulating excitation-contraction coupling can limit the translation of experimental findings from animal models to human physiology and undermine the assessment of drugs’ efficacy and safety. Here, we built a suite of translators for quantitatively mapping electrophysiological responses in ventricular myocytes across species. We trained these statistical operators using a broad dataset obtained by simulating populations of our biophysically detailed computational models of action potential and Ca²⁺ transient in mouse, rabbit, and human. We then tested our translators against experimental data describing the response t

SUBMITTER: Morotti S 

PROVIDER: S-EPMC8598003 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature