High unbound flucloxacillin fraction in critically ill patients.

ABSTRACT:

Objectives

To describe the unbound and total flucloxacillin pharmacokinetics in critically ill patients and to define optimal dosing strategies.

Patients and methods

Observational multicentre study including a total of 33 adult ICU patients receiving flucloxacillin, given as intermittent or continuous infusion. Pharmacokinetic sampling was performed on two occasions on two different days. Total and unbound flucloxacillin concentrations were measured and analysed using non-linear mixed-effects modelling. Serum albumin was added as covariate on the maximum binding capacity and endogenous creatinine clearance (CLCR) as covariate for renal function. Monte Carlo simulations were performed to predict the unbound flucloxacillin concentrations for different dosing strategies and dif

SUBMITTER: Wallenburg E 

PROVIDER: S-EPMC8598283 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature