A Whole-Grain Diet Increases Whole-Body Protein Balance Compared with a Macronutrient-Matched Refined-Grain Diet.

ABSTRACT:

Background

There are limited data from randomized control trials to support or refute the contention that whole-grains can enhance protein metabolism in humans.

Objectives

To examine: 1) the clinical effects of a whole-grain diet on whole-body protein turnover; 2) the cellular effects of whole-grains on protein synthesis in skeletal muscle cells; and 3) the population effects of whole-grain intake on age-related muscle loss.

Methods

Adults with overweight/obesity (n = 14; age = 40 ± 7 y; BMI = 33 ± 5 kg/m²) were recruited into a crossover, randomized controlled trial (NCT01411540) in which isocaloric, macronutrient-matched whole-grain and refined-grain diets were fully provisioned for two 8-wk periods. Diets differed only in the

SUBMITTER: Mey JT 

PROVIDER: S-EPMC8598768 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature