Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies.

ABSTRACT:

Objective

Irritable bowel syndrome (IBS) is a chronic disorder associated with an abnormal gastrointestinal microbiome. Microbiome-host interactions are known to influence organ function including in the central nervous system; thus, we sought to identify whether IBS may be a risk factor for the development of glaucoma.

Design

Two prospective cohort studies.

Subjects

The 1958 United Kingdom Birth Cohort (UKBC; 9091 individuals) and the Danish National Registry of Patients (DNRP; 62,541 individuals with IBS and 625,410 matched general population cohort members).

Methods

In the UKBC, participants were surveyed throughout life (including at ages 42 and 50). The DNRP contains records of hospital-based contacts and prescription data from the national prescription da

SUBMITTER: McPherson ZE 

PROVIDER: S-EPMC8598964 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature