RNA sequencing reveals induction of specific renal inflammatory pathways in a rat model of malignant hypertension.

ABSTRACT: In malignant hypertension, far more severe kidney injury occurs than in the "benign" form of the disease. The role of high blood pressure and the renin-angiotensin-aldosterone system is well recognized, but the pathogenesis of the renal injury of malignant hypertension (MH) remains incompletely understood. Using the rat model of two-kidney, one-clip renovascular hypertension in which some but not all animals develop MH, we performed a transcriptomic analysis of gene expression by RNA sequencing to identify transcriptional changes in the kidney cortex specific for MH. Differential gene expression was assessed in three groups: MH, non-malignant hypertension (NMH), and normotensive, sham-operated controls. To distinguish MH from NMH, we considered two factors: weight loss and typical renovasc

SUBMITTER: Menendez-Castro C 

PROVIDER: S-EPMC8599225 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature