Co-phosphorylation networks reveal subtype-specific signaling modules in breast cancer.

ABSTRACT:

Motivation

Protein phosphorylation is a ubiquitous mechanism of post-translational modification that plays a central role in cellular signaling. Phosphorylation is particularly important in the context of cancer, as downregulation of tumor suppressors and upregulation of oncogenes by the dysregulation of associated kinase and phosphatase networks are shown to have key roles in tumor growth and progression. Despite recent advances that enable large-scale monitoring of protein phosphorylation, these data are not fully incorporated into such computational tasks as phenotyping and subtyping of cancers.

Results

We develop a network-based algorithm, CoPPNet, to enable unsupervised subtyping of cancers using phosphorylation data. For this purpose, we integrate prior knowledge on ev

SUBMITTER: Ayati M 

PROVIDER: S-EPMC8599309 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature