The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone.

ABSTRACT: Objective: Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillations (HFOs) could be useful markers of the EZ. Hence, we aimed to detect the EZ using interictal spikes and investigated whether the onset area of interictal spike-related HFOs was within the EZ. Methods: The EZ is considered to be included in the resection area among patients with seizure-free outcomes after surgery. Using a complex demodulation technique, we developed a method to determine the onset channels of interictal spike-related ripples (HFOs of 80-200 Hz) and investigated

SUBMITTER: Numata-Uematsu Y 

PROVIDER: S-EPMC8599368 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature