Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease.

ABSTRACT: Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophysiological studies have shown distinct cortical oscillations with a significant contribution of the cerebellum during postural control tasks in healthy individuals. Methods: We investigated cortical and mid-cerebellar oscillatory activity via electroencephalography (EEG) during a postural control task in 10 PD patients with postural instability (PDPI+), 11 PD patients without postural instability (PDPI-), and 15 age-matched healthy control participants. Relative spectral power was

SUBMITTER: Bosch TJ 

PROVIDER: S-EPMC8599431 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature