Cementocyte alterations associated with experimentally induced cellular cementum apposition in Hyp mice.

ABSTRACT:

Background

Cellular cementum, a mineralized tissue covering apical tooth roots, grows by apposition to maintain the tooth in its occlusal position. We hypothesized that resident cementocytes would show morphological changes in response to cementum apposition, possibly implicating a role in cementum biology.

Methods

Mandibular first molars were induced to super-erupt (EIA) by extraction of maxillary molars, promoting rapid new cementum formation. Tissue and cell responses were analyzed at 6 and/or 21 days post-procedure (dpp).

Results

High-resolution micro-computed tomography (micro-CT) and confocal laser scanning microscopy showed increased cellular cementum by 21 dpp. Transmission electron microscopy (TEM) revealed that cementocytes under EIA were 50% larger than con

SUBMITTER: Lira Dos Santos EJ 

PROVIDER: S-EPMC8599496 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature