Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.

ABSTRACT:

Background

Mucus plugging can worsen asthma control, lead to reduced lung function and fatal exacerbations. MUC5AC is the secretory mucin implicated in mucus plugging, and MUC5AC gene expression has been associated with development of airway obstruction and asthma exacerbations in urban children with asthma. However, the genetic determinants of MUC5AC expression are not established.

Objectives

This study sought to assess single-nucleotide polymorphisms (SNPs) that influence MUC5AC expression and relate to pulmonary functions in childhood asthma.

Methods

This study used RNA-sequencing data from upper airway samples and performed cis-expression quantitative trait loci (eQTL) and allele-specific expression analyses in 2 cohorts of predominantly Black and Hispanic urban c

SUBMITTER: Altman MC 

PROVIDER: S-EPMC8599524 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature