Three-Dimensional Modeling of the Structural Microenvironment in Post-Traumatic War Wounds.

ABSTRACT:

Background

The development of post-traumatic heterotopic ossification (HO) is a common, undesirable sequela in patients with high-energy (war-related) extremity injuries. While inflammatory and osteoinductive signaling pathways are known to be involved in the development and progression of post-traumatic HO, features of the structural microenvironment within which the ectopic bone begins to form remain poorly understood. Thus, increasing our knowledge of molecular and structural changes within the healing wound may help elucidate the pathogenesis of post-traumatic HO and aid in the development of specific treatment and/or prevention strategies.

Methods

In this study, we performed high-resolution microscopy and biochemical analysis of tissues obtained from traumatic war wound

SUBMITTER: Christopherson GT 

PROVIDER: S-EPMC8599535 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature