Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.

ABSTRACT: It has been demonstrated that elamipretide (SS-31) rescues age-related functional deficits in the heart but the full set of mechanisms behind this have yet to be determined. We investigated the hypothesis that elamipretide influences post-translational modifications to heart proteins. The S-glutathionylation and phosphorylation proteomes of mouse hearts were analyzed using shotgun proteomics to assess the effects of aging on these post-translational modifications and the ability of the mitochondria-targeted drug elamipretide to reverse age-related changes. Aging led to an increase in oxidation of protein thiols demonstrated by increased S-glutathionylation of cysteine residues on proteins from Old (24 months old at the start of the study) mouse hearts compared to Young (5-6 months old). Th

SUBMITTER: Whitson JA 

PROVIDER: S-EPMC8599536 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature