Pterocarpus marsupium extract extends replicative lifespan in budding yeast.

ABSTRACT: As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has served as a premier model organism for identifying genetic and molecular factors that modulate cellular aging and is a powerful system in which to evaluate candidate longevity interventions. Here we screened a collection of natural products and natural product mixtures for effects on the growth rate, mTOR-mediated growth inhibition, and replicative lifespan. No mTOR inhibitory activity was detected, but several of the treatments affected growth rate and lifespan. The strongest lifespan shortening effects were observed for green tea extract and ber

SUBMITTER: Lee MB 

PROVIDER: S-EPMC8599564 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature