Untargeted GC-MS-Based Metabolomics for Early Detection of Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common malignant gastrointestinal cancers in the world with a 5-year survival rate of approximately 68%. Although researchers accumulated many scientific studies, its pathogenesis remains unclear yet. Detecting and removing these malignant polyps promptly is the most effective method in CRC prevention. Therefore, the analysis and disposal of malignant polyps is conducive to preventing CRC.

Methods

In the study, metabolic profiling as well as diagnostic biomarkers for CRC was investigated using untargeted GC-MS-based metabolomics methods to explore the intervention approaches. In order to better characterize the variations of tissue and serum metabolic profiles, orthogonal partial least-square discriminant analysis was car

SUBMITTER: Zhu G 

PROVIDER: S-EPMC8599589 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature