Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis.

ABSTRACT: The kidney is a complex organ composed of more than 30 terminally differentiated cell types that all are required to perform its numerous homeostatic functions. Defects in kidney development are a significant cause of chronic kidney disease in children, which can lead to kidney failure that can only be treated by transplant or dialysis. A better understanding of molecular mechanisms that drive kidney development is important for designing strategies to enhance renal repair and regeneration. In this study, we profiled gene expression in the developing mouse kidney at embryonic day 14.5 at single-cell resolution. Consistent with previous studies, clusters with distinct transcriptional signatures clearly identify major compartments and cell types of the developing kidney. Cell cycle activity

SUBMITTER: Bais AS 

PROVIDER: S-EPMC8599654 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature