Biphasic (5-2%) oxygen concentration strategy significantly improves the usable blastocyst and cumulative live birth rates in in vitro fertilization.

ABSTRACT: Oxygen (O₂) concentration is approximately 5% in the fallopian tube and 2% in the uterus in humans. A "back to nature" approach could increase in vitro fertilization (IVF) outcomes. This hypothesis was tested in this monocentric observational retrospective study that included 120 couples who underwent two IVF cycles between 2014 and 2019. Embryos were cultured at 5% from day 0 (D0) to D5/6 (monophasic O₂ concentration strategy) in the first IVF cycle, and at 5% O₂ from D0 to D3 and 2% O₂ from D3 to D5/6 (biphasic O₂ concentration strategy) in the second IVF cycle. The total and usable blastocyst rates (44.4% vs. 54.8%, p = 0.049 and 21.8% vs. 32.8%, p = 0.002, respectively) and the cumulative live birth rate (17.9% vs. 44.1%, p = 0.027

SUBMITTER: Brouillet S 

PROVIDER: S-EPMC8599669 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature