Functional Connectivity Predicts Individual Development of Inhibitory Control during Adolescence.

ABSTRACT: Derailment of inhibitory control (IC) underlies numerous psychiatric and behavioral disorders, many of which emerge during adolescence. Identifying reliable predictive biomarkers that place the adolescents at elevated risk for future IC deficits can help guide early interventions, yet the scarcity of longitudinal research has hindered the progress. Here, using a large-scale longitudinal dataset in which the same subjects performed a stop signal task during functional magnetic resonance imaging at ages 14 and 19, we tracked their IC development individually and tried to find the brain features predicting their development by constructing prediction models using 14-year-olds' functional connections within a network or between a pair of networks. The participants had distinct between-subject

SUBMITTER: Wang H 

PROVIDER: S-EPMC8599716 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature