Simulating intervertebral disc cell behaviour within 3D multifactorial environments.

ABSTRACT:

Motivation

Low back pain is responsible for more global disability than any other condition. Its incidence is closely related to intervertebral disc (IVD) failure, which is likely caused by an accumulation of microtrauma within the IVD. Crucial factors in microtrauma development are not entirely known yet, probably because their exploration in vivo or in vitro remains tremendously challenging. In silico modelling is, therefore, definitively appealing, and shall include approaches to integrate influences of multiple cell stimuli at the microscale. Accordingly, this study introduces a hybrid Agent-based (AB) model in IVD research and exploits network modelling solutions in systems biology to mimic the cellular behaviour of Nucleus Pulposus cells exposed to a 3D multifactorial biochem

SUBMITTER: Baumgartner L 

PROVIDER: S-EPMC8599729 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature