Association of lactate dehydrogenase with mortality in incident hemodialysis patients.

ABSTRACT:

Background

Lactate dehydrogenase (LDH) plays a role in the glucose metabolism of the human body. Higher LDH levels have been linked to mortality in various cancer types; however, the relationship between LDH and survival in incident hemodialysis (HD) patients has not yet been examined. We hypothesized that higher LDH level is associated with higher death risk in these patients.

Methods

We examined the association of baseline and time-varying serum LDH with all-cause, cardiovascular and infection-related mortality among 109 632 adult incident HD patients receiving care from a large dialysis organization in the USA during January 2007 to December 2011. Baseline and time-varying survival models were adjusted for demographic variables and available clinical and laboratory surrog

SUBMITTER: Ryu SY 

PROVIDER: S-EPMC8599773 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature