Personalizing Breast Cancer Screening Based on Polygenic Risk and Family History.

ABSTRACT:

Background

We assessed the clinical utility of a first-degree breast cancer family history and polygenic risk score (PRS) to inform screening decisions among women aged 30-50 years.

Methods

Two established breast cancer models evaluated digital mammography screening strategies in the 1985 US birth cohort by risk groups defined by family history and PRS based on 313 single nucleotide polymorphisms. Strategies varied in initiation age (30, 35, 40, 45, and 50 years) and interval (annual, hybrid, biennial, triennial). The benefits (breast cancer deaths averted, life-years gained) and harms (false-positive mammograms, overdiagnoses) were compared with those seen with 3 established screening guidelines.

Results

Women with a breast cancer family history who initiated biennia

SUBMITTER: van den Broek JJ 

PROVIDER: S-EPMC8599807 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature