Determination of the two-component systems regulatory network reveals core and accessory regulations across Pseudomonas aeruginosa lineages.

ABSTRACT: Pseudomonas aeruginosa possesses one of the most complex bacterial regulatory networks, which largely contributes to its success as a pathogen. However, most of its transcription factors (TFs) are still uncharacterized and the potential intra-species variability in regulatory networks has been mostly ignored so far. Here, we used DAP-seq to map the genome-wide binding sites of all 55 DNA-binding two-component systems (TCSs) response regulators (RRs) across the three major P. aeruginosa lineages. The resulting networks encompass about 40% of all genes in each strain and contain numerous new regulatory interactions across most major physiological processes. Strikingly, about half of the detected targets are specific to only one or two strains, revealing a previously unknown large functional

SUBMITTER: Trouillon J 

PROVIDER: S-EPMC8599809 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature