A Single Microbiome Gene Alters Murine Susceptibility to Acute Arsenic Exposure.

ABSTRACT: Environmental toxicant exposure contributes to morbidity and mortality of many human diseases. With respect to arsenic, microbially driven chemical transformations dictate its toxicity and mobility in virtually every environment yet studied, so a general hypothesis is that the human gut microbiome determines disease outcome following exposure. However, the complex nature of the gut microbiome and the myriad of potential interactions with human cells/tissues make it challenging to quantify the influence of specific arsenic-active functions-a requisite step in developing effective disease prevention and/or clinical intervention strategies. To control both mammalian and microbial function during toxicant exposure, we genetically defined the gut microbiome of mice using only Escherichia coli s

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8599829 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature