Brain-Responsive Neurostimulation for Loss of Control Eating: Early Feasibility Study.

ABSTRACT:

Background

Loss of control (LOC) is a pervasive feature of binge eating, which contributes significantly to the growing epidemic of obesity; approximately 80 million US adults are obese. Brain-responsive neurostimulation guided by the delta band was previously found to block binge-eating behavior in mice. Following novel preclinical work and a human case study demonstrating an association between the delta band and reward anticipation, the US Food and Drug Administration approved an Investigational Device Exemption for a first-in-human study.

Objective

To assess feasibility, safety, and nonfutility of brain-responsive neurostimulation for LOC eating in treatment-refractory obesity.

Methods

This is a single-site, early feasibility study with a randomized, single-blinde

SUBMITTER: Wu H 

PROVIDER: S-EPMC8599841 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature