The impact of lactate clearance on outcomes according to infection sites in patients with sepsis: a retrospective observational study.

ABSTRACT: Whether lactate clearance (LC) influences outcomes differently depending on the infection site in sepsis cases is not fully elucidated. Herein, we analyzed LC's clinical utility as a predictor of patient outcomes according to infection site. This retrospective study, conducted at two tertiary emergency critical care medical centers in Japan, included patients with sepsis or septic shock. The associations between infection site (lungs vs. other organs) and in-hospital mortality and ventilator-free days (VFDs) were evaluated using univariable and multivariate analyses. We assessed LC's ability to predict in-hospital mortality using the area under the receiver operating characteristic curve. Among 369 patients with sepsis, infection sites were as follows: lungs, 186 (50.4%); urinary tract, 45

SUBMITTER: Sugimoto M 

PROVIDER: S-EPMC8599851 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature