Incident Type 2 Diabetes Duration and Cancer Risk: A Prospective Study in Two US Cohorts.

ABSTRACT:

Background

The influence of type 2 diabetes mellitus (T2D) duration on cancer incidence remains poorly understood.

Methods

We prospectively followed for cancer incidence 113 429 women in the Nurses' Health Study (1978-2014) and 45 604 men in the Health Professionals Follow-up Study (1988-2014) who were free of diabetes and cancer at baseline. Cancer incidences were ascertained by review of medical records.

Results

In the multivariable-adjusted model incident, T2D was associated with higher risk of cancers in the colorectum, lung, pancreas, esophagus, liver, thyroid, breast, and endometrium. The pooled hazard ratios (HRs) ranged from 1.21 (95% confidence interval [CI] = 1.06 to 1.38) for colorectal cancer to 3.39 (95% CI = 2.24 to 5.12) for liver cancer. For both compo

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8599903 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature