Metabolic Imbalance Effect on Retinal Muller Glial Cells Reprogramming Capacity: Involvement of Histone Deacetylase SIRT6.

ABSTRACT: Retinal Müller glial cells (MGs) are among the first to demonstrate metabolic changes during retinal disease and are a potential source of regenerative cells. In response to a harmful stimulus, they can dedifferentiate acquiring neural stem cells properties, proliferate and migrate to the damaged retinal layer and differentiate into lost neurons. However, it is not yet known how this reprogramming process is regulated in mammals. Since glucose and oxygen are important regulatory elements that may help directing stem cell fate, we aimed to study the effect of glucose variations and oxidative stress in Müller cells reprogramming capacity and analyze the participation the histone deacetylase SIRT6, as an epigenetic modulator of this process. We found that the combination of high glucose and o

SUBMITTER: Sanhueza Salas LF 

PROVIDER: S-EPMC8599966 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature