Whole transcriptome analysis of high and low IFN-α producers reveals differential response patterns following rhinovirus stimulation.

ABSTRACT:

Objectives

Viral respiratory infections cause considerable morbidity and economic loss. While rhinoviruses (RV) typically cause little more than the common cold, they can produce severe infections and disease exacerbations in susceptible individuals, such as those with asthma. Variations in the regulation of key antiviral cytokines, particularly type I interferon (IFN-α and IFN-β), may contribute to RV susceptibility. To understand this variability, we compared the transcriptomes of high and low type I IFN producers.

Methods

Blood mononuclear cells from 238 individuals with or without asthma were cultured in the presence or absence of RV. Those samples demonstrating high or low RV-stimulated IFN-α production (N = 75) underwent RNA-sequencing.

Results

Gene expression p

SUBMITTER: Murray LM 

PROVIDER: S-EPMC8599968 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature