ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress.

ABSTRACT: Autophagy is a highly conserved intracellular process that preserves cellular homeostasis by mediating the lysosomal degradation of virtually any component of the cytoplasm. Autophagy is a key instrument of cellular response to several stresses, including endoplasmic reticulum (ER) stress. Cancer cells have developed high dependency on autophagy to overcome the hostile tumor microenvironment. Thus, pharmacological activation or inhibition of autophagy is emerging as a novel antitumor strategy. ERK5 is a novel member of the MAP kinase family that is activated in response to growth factors and different forms of stress. Recent work has pointed ERK5 as a major player controlling cancer cell proliferation and survival. Therefore small-molecule inhibitors of ERK5 have shown promising therapeuti

SUBMITTER: Gamez-Garcia A 

PROVIDER: S-EPMC8600073 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature