Obesity is associated with reduced cerebral blood flow - modified by physical activity.

ABSTRACT: This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBF_GM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBF_GM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m², WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBF_GM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBF_GM (p ≤ .011); there was no significant red

SUBMITTER: Knight SP 

PROVIDER: S-EPMC8600128 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature