RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway.

ABSTRACT:

Background

Glioblastoma (GBM) is a prevalent brain malignancy with an extremely poor prognosis, which is attributable to its invasive biological behavior. The RNA-binding motif protein 8A (RBM8A) has different effects on various human cancers. However, the role of RBM8A in GBM progression remains unclear.

Methods

We investigated the expression levels of RBM8A in 94 GBM patients and explored the correlation between RBM8A expression and patient prognosis. Using in vitro and in vivo assays, combined with GBM sequencing data from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), we examined whether and how RBM8A contributes to GBM progression.

Results

RBM8A was up-regulated in GBM tissues, and its higher expression correlated with wo

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8600138 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature