Innate Memory Reprogramming by Gold Nanoparticles Depends on the Microbial Agents That Induce Memory.

ABSTRACT: Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as such, could trigger an inflammatory reaction in monocytes and macrophages and could therefore be also able to induce innate memory. Here, we have evaluated the capacity of engineered gold nanoparticles (AuNPs) to induce a memory response or to modulate the memory responses induced by microbial agents. Microbial agents used were in soluble vs. particulate form (MDP and the gram-positive bacteria Staphylococcus aureus; β-glucan and the β-glucan-producing fungi C. albicans), and as whole microrganisms that were either kil

SUBMITTER: Swartzwelter BJ 

PROVIDER: S-EPMC8600232 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature