The Immunoglobulin Superfamily Member Basigin Is Required for Complex Dendrite Formation in Drosophila.

ABSTRACT: Coordination of dendrite growth with changes in the surrounding substrate occurs widely in the nervous system and is vital for establishing and maintaining neural circuits. However, the molecular basis of this important developmental process remains poorly understood. To identify potential mediators of neuron-substrate interactions important for dendrite morphogenesis, we undertook an expression pattern-based screen in Drosophila larvae, which revealed many proteins with expression in dendritic arborization (da) sensory neurons and in neurons and their epidermal substrate. We found that reporters for Basigin, a cell surface molecule of the immunoglobulin (Ig) superfamily previously implicated in cell-cell and cell-substrate interactions, are expressed in da sensory neurons and epide

SUBMITTER: Shrestha BR 

PROVIDER: S-EPMC8600269 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature