Posterior cortical atrophy phenotypic heterogeneity revealed by decoding ¹⁸F-FDG-PET.

ABSTRACT: Posterior cortical atrophy is a neurodegenerative syndrome with a heterogeneous clinical presentation due to variable involvement of the left, right, dorsal and ventral parts of the visual system, as well as inconsistent involvement of other cognitive domains and systems. ¹⁸F-fluorodeoxyglucose (FDG)-PET is a sensitive marker for regional brain damage or dysfunction, capable of capturing the pattern of neurodegeneration at the single-participant level. We aimed to leverage these inter-individual differences on FDG-PET imaging to better understand the associations of heterogeneity of posterior cortical atrophy. We identified 91 posterior cortical atrophy participants with FDG-PET data and abstracted demographic, neurologic, neuropsychological and Alzheimer's disease biomarker dat

SUBMITTER: Townley RA 

PROVIDER: S-EPMC8600283 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature