Associations of Hypothyroxinemia With Risk of Preeclampsia-Eclampsia and Gestational Hypertension.

ABSTRACT:

Objective

To investigate the association between hypothyroxinemia and the risk of preeclampsia-eclampsia and gestational hypertension.

Design

Historical cohort study.

Methods

The study included pregnant individuals who delivered live-born singletons and had at least one thyroid function assessment during pregnancy at a tertiary hospital. Hypothyroxinemia was defined as thyroid-stimulating hormone (TSH) levels within the normal reference range and free thyroxine (FT4) levels lower than the tenth percentile. Risk ratios (RRs) with 95% confidence intervals (95% CIs) for preeclampsia-eclampsia and gestational hypertension between women with and without a diagnosis of hypothyroxinemia during pregnancy were estimated using a generalized estimating equation model.

Results

SUBMITTER: Su X 

PROVIDER: S-EPMC8600315 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature